How to get from Rome to St Louis: connecting flights, about 14h 49m total

Flights from Rome to St Louis

Pick a departure date to see flights and seller prices

We search agencies and airlines for your day: nonstop and connecting flights, baggage, departure and arrival times.

Prices by day: Rome to St Louis

Lowest one-way price in dollars from recent searches, cheap days in green. Press a day to see flights and exact prices.

Best fares from Rome to St Louis

Lowest one-way prices found by recent searches for the next 120 days; press a card to search that date

Cheapest one-way $518 8 December 2026, with a connection Cheapest month December 2026 tickets from $518

Where to connect

Options with one connection, fastest first

fastest, via Chicago: 14h 49m
two tickets, via Chicago: $909
connection options: 5
straight-line distance: 5,058 mi (8,140 km)

fastest

Via Chicago

United States

14h 49m

with the connection

Rome to Chicago flight 10h 25m

Connection of about 3h

Chicago to St Louis flight 1h 24m

two ticketsfrom $909

Via Frankfurt

Germany

14h 53m

with the connection

Rome to Frankfurt flight 2h

Connection of about 3h Arrival: Frankfurt, Frankfurt - Hahn. Departure to St Louis: Frankfurt.

Frankfurt to St Louis flight 9h 53m

Via Toronto

Canada

14h 53m

with the connection

Rome to Toronto flight 9h 40m

Connection of about 3h

Toronto to St Louis flight 2h 13m

Via Detroit

United States

15h 18m

with the connection

Rome to Detroit flight 10h 33m

Connection of about 3h

Detroit to St Louis flight 1h 45m

Via Philadelphia

United States

15h 21m

with the connection

Rome to Philadelphia flight 9h 45m

Connection of about 3h

Philadelphia to St Louis flight 2h 36m

One ticket or two

How the options are calculated and what to keep in mind at the connection

Flight times come from the nonstop schedule (estimated from the distance where there is no schedule), with 3h allowed for the connection. The price of an option is the sum of the lowest known fares for each leg; their dates may not match, so treat it as a guide. The search shows tickets for your dates, including connections on a single ticket.

Nearest nonstop flights

The closest you can get without a connection

From Rome to cities closest to St Louis

Rome to Chicago Chicago: 262 mi (422 km) from St Louis, flight 10h 25m from $390 Rome to Detroit Detroit: 455 mi (732 km) from St Louis, flight 10h 33m from $464 Rome to Atlanta Atlanta: 467 mi (752 km) from St Louis, flight 11h 16m Rome to Dallas Dallas: 548 mi (882 km) from St Louis, flight 12h 5m from $475 Rome to Charlotte Charlotte: 567 mi (913 km) from St Louis, flight 10h 33m from $497 Rome to Toronto Toronto: 661 mi (1,063 km) from St Louis, flight 9h 40m from $376

To St Louis from cities closest to Rome

Frankfurt to St Louis Frankfurt: 594 mi (956 km) from Rome, flight 9h 53m Boston to St Louis Boston: 4,092 mi (6,586 km) from Rome, flight 3h 10m from $173 New York to St Louis New York: 4,281 mi (6,890 km) from Rome, flight 2h 55m from $141 Philadelphia to St Louis Philadelphia: 4,361 mi (7,019 km) from Rome, flight 2h 36m from $320 Toronto to St Louis Toronto: 4,401 mi (7,082 km) from Rome, flight 2h 13m Washington to St Louis Washington: 4,485 mi (7,218 km) from Rome, flight 2h 30m

Frequently asked questions

Is there a nonstop flight from Rome to St Louis?

There are no nonstop flights in the schedule. You will need a connection, the fastest is via Chicago.

What is the fastest way to fly from Rome to St Louis?

Via Chicago: 10h 25m to the connection, 1h 24m after it, about 14h 49m in total with 3h for the connection.

How much does a flight from Rome to St Louis with a connection cost?

Two nonstop tickets via Chicago from $909. This is the sum of the lowest known prices for each leg, and their dates may not match.

Which cities can you connect in between Rome and St Louis?

Chicago (14h 49m total), Frankfurt (14h 53m total), Toronto (14h 53m total), Detroit (15h 18m total) and Philadelphia (15h 21m total).

How far is St Louis from Rome?

5,058 mi (8,140 km) in a straight line between the cities.

How much time should I allow for the connection?

The options allow 3h. On a single ticket the carrier is responsible for the connection; on separate tickets you set the margin yourself, allowing time to collect and re-check your bags.