How to get from Indianapolis to St Louis: connecting flights, about 5h 45m total

Flights from Indianapolis to St Louis

Pick a departure date to see flights and seller prices

We search agencies and airlines for your day: nonstop and connecting flights, baggage, departure and arrival times.

Best fares from Indianapolis to St Louis

Lowest one-way prices found by recent searches for the next 120 days; press a card to search that date

Cheapest one-way $257 14 November 2026, with a connection Cheapest in the next 7 days $257 14 November, Sat Cheapest weekend departure $257 Sat, 14 November 2026 Cheapest month November 2026 tickets from $257

Where to connect

Options with one connection, fastest first

fastest, via Chicago: 5h 45m
two tickets, via Chicago: $162
connection option: 1
straight-line distance: 231 mi (371 km)

fastest

Via Chicago

5h 45m

with the connection

Indianapolis to Chicago flight 1h 21m

Connection of about 3h

Chicago to St Louis flight 1h 24m

two ticketsfrom $162

One ticket or two

How the options are calculated and what to keep in mind at the connection

Flight times come from the nonstop schedule (estimated from the distance where there is no schedule), with 3h allowed for the connection. The price of an option is the sum of the lowest known fares for each leg; their dates may not match, so treat it as a guide. The search shows tickets for your dates, including connections on a single ticket.

Nearest nonstop flights

The closest you can get without a connection

From Indianapolis to cities closest to St Louis

Indianapolis to Kansas City Kansas City: 238 mi (383 km) from St Louis, flight 1h 35m from $275 Indianapolis to Chicago Chicago: 262 mi (422 km) from St Louis, flight 1h 21m from $92 Indianapolis to Atlanta Atlanta: 467 mi (752 km) from St Louis, flight 1h 36m from $126 Indianapolis to Dallas Dallas: 548 mi (882 km) from St Louis, flight 2h 32m from $181 Indianapolis to Charlotte Charlotte: 567 mi (913 km) from St Louis, flight 1h 47m from $77 Indianapolis to Washington Washington: 709 mi (1,141 km) from St Louis, flight 1h 45m from $82

To St Louis from cities closest to Indianapolis

Chicago to St Louis Chicago: 165 mi (265 km) from Indianapolis, flight 1h 24m from $72 Detroit to St Louis Detroit: 240 mi (386 km) from Indianapolis, flight 1h 45m Nashville to St Louis Nashville: 252 mi (405 km) from Indianapolis, flight 1h 15m Cleveland to St Louis Cleveland: 263 mi (423 km) from Indianapolis, flight 1h 43m from $170 Pittsburgh to St Louis Pittsburgh: 329 mi (529 km) from Indianapolis, flight 1h 50m from $141 Atlanta to St Louis Atlanta: 428 mi (688 km) from Indianapolis, flight 1h 45m from $107

Frequently asked questions

Is there a nonstop flight from Indianapolis to St Louis?

There are no nonstop flights in the schedule. You will need a connection, the fastest is via Chicago.

What is the fastest way to fly from Indianapolis to St Louis?

Via Chicago: 1h 21m to the connection, 1h 24m after it, about 5h 45m in total with 3h for the connection.

How much does a flight from Indianapolis to St Louis with a connection cost?

Two nonstop tickets via Chicago from $162. This is the sum of the lowest known prices for each leg, and their dates may not match.

How far is St Louis from Indianapolis?

231 mi (371 km) in a straight line between the cities.

How much time should I allow for the connection?

The options allow 3h. On a single ticket the carrier is responsible for the connection; on separate tickets you set the margin yourself, allowing time to collect and re-check your bags.