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Cheap flights from Des Moines to Chicago

55 nonstop flights a week, 7 of them today. Operated by 3 airlines, about 1h 40m in the air, 309 mi (498 km). Tickets from $108, nonstop from $94.

Flights from Des Moines to Chicago

Pick a departure date to see flights and seller prices

We search agencies and airlines for your day: nonstop and connecting flights, baggage, departure and arrival times.

Filters

Best fares from Des Moines to Chicago

Lowest one-way prices found by recent searches for the next 120 days; press a card to search that date

Cheapest one-way $108 12 November 2026, nonstop Cheapest nonstop $108 12 November 2026, American Airlines Cheapest in the next 7 days $108 Tomorrow Cheapest weekend departure $223 Sat, 14 November 2026 Cheapest month November 2026 tickets from $108

Des Moines to Chicago at a glance

flight time, from 1h 15m to 1h 56m
1h 40m
straight-line distance
309 mi (498 km)
flights a week
55
flights today
7
first and last departure
05:20 - 11:23
lowest price, nonstop, 12 November
$108
lowest nonstop price
$94
airlines
3

Des Moines to Chicago flight schedule

55 flights a week, 7 today, 44 seasonal or one-off. Departure and arrival times are local.

FlightDepartsArrivesDurationDaysAircraft
WN 1853
Southwest Airlines
05:20 Des Moines International
06:45 Chicago Midway International
1h 25m
Sat
Boeing 737
WN 1865
Southwest Airlines
05:20 Des Moines International
06:45 Chicago Midway International
1h 25m
Sat
WN 1865
Southwest Airlines
05:25 Des Moines International
06:55 Chicago Midway International
1h 30m
Mon, Thu, Fri, Sun
WN 1865
Southwest Airlines
06:00 Des Moines International
07:25 Chicago Midway International
1h 25m
Mon, Tue, Wed, Thu
UA 5308
United Airlines
06:05 Des Moines International
07:42 , terminal 2
1h 37m
Daily
Embraer 175
AA 4367
American Airlines
07:11 Des Moines International
09:04 , terminal 3
1h 53m
Mon, Thu, Fri, Sat, Sun
Embraer EMB 175
AA 4367
American Airlines
07:23 Des Moines International
09:10 , terminal 3
1h 47m
Daily
Embraer EMB 175
UA 2668
United Airlines
08:00 Des Moines International
09:40 , terminal 1
1h 40m
Daily
Airbus A319
AA 6242
American Airlines
09:25 Des Moines International
11:14 , terminal 3
1h 49m
Fri, Sat, Sun
Canadair reg jet 700
AA 6284
American Airlines
09:25 Des Moines International
11:10 , terminal 3
1h 45m
Daily
Canadair reg jet 700
AA 6242
American Airlines
09:31 Des Moines International
11:20 , terminal 3
1h 49m
Mon, Thu
Canadair reg jet 700
UA 5439
United Airlines
09:50 Des Moines International
11:29 , terminal 2
1h 39m
Mon, Thu
Embraer 175
UA 5439
United Airlines
09:55 Des Moines International
11:34 , terminal 2
1h 39m
Tue, Wed, Fri, Sat, Sun
Embraer 175
UA 5304
United Airlines
11:22 Des Moines International
12:58 , terminal 2
1h 36m
Mon, Tue, Thu, Fri, Sun
Embraer 175
UA 5304
United Airlines
11:23 Des Moines International
13:01 , terminal 2
1h 38m
Wed, Sat
Embraer 175

Seasonal and one-off flights

Not operating in the next two weeks. The first of them is on 24 November.

FlightDepartsArrivesDurationDaysAircraft
WN 1865
Southwest Airlines
05:10 Des Moines International
06:30 Chicago Midway International
1h 20m
Seasonal
Boeing 737
AA 6242
American Airlines
09:30 Des Moines International
11:19 , terminal 3
1h 49m
Seasonal
Canadair reg jet 700
UA 5304
United Airlines
11:24 Des Moines International
13:00 , terminal 2
1h 36m
Seasonal
Embraer 175
WN 957
Southwest Airlines
05:10 Des Moines International
06:30 Chicago Midway International
1h 20m
Seasonal
Boeing 737
AA 4367
American Airlines
09:15 Des Moines International
11:05 , terminal 3
1h 50m
Seasonal
Embraer EMB 175
UA 2041
United Airlines
08:00 Des Moines International
09:40 , terminal 1
1h 40m
Seasonal
Airbus A319
UA 5279
United Airlines
09:30 Des Moines International
11:12 , terminal 2
1h 42m
Seasonal
Embraer 175
UA 6024
United Airlines
06:15 Des Moines International
07:57 , terminal 2
1h 42m
Seasonal
Embraer 175
AA 4388
American Airlines
07:14 Des Moines International
09:10 , terminal 3
1h 56m
Seasonal
Embraer EMB 175
AA 6292
American Airlines
09:23 Des Moines International
11:10 , terminal 3
1h 47m
Seasonal
Canadair reg jet 700
UA 2041
United Airlines
06:15 Des Moines International
07:56 , terminal 1
1h 41m
Seasonal
Airbus A320
UA 5798
United Airlines
05:00 Des Moines International
06:47 , terminal 2
1h 47m
Seasonal
Embraer 175
AA 3601
American Airlines
05:30 Des Moines International
07:20 , terminal 3
1h 50m
Seasonal
Embraer 170
UA 5217
United Airlines
09:32 Des Moines International
11:17 , terminal 2
1h 45m
Seasonal
Embraer 175
AA 3923
American Airlines
09:53 Des Moines International
11:30 , terminal 3
1h 37m
Seasonal
Embraer 170
UA 6040
United Airlines
11:21 Des Moines International
12:59 , terminal 2
1h 38m
Seasonal
AA 3601
American Airlines
05:12 Des Moines International
06:59 , terminal 3
1h 47m
Seasonal
Embraer 170
AA 4558
American Airlines
09:40 Des Moines International
11:33 , terminal 3
1h 53m
Seasonal
Embraer EMB 175
AA 3923
American Airlines
09:21 Des Moines International
10:58 , terminal 3
1h 37m
Seasonal
Embraer 170
UA 5279
United Airlines
09:25 Des Moines International
11:10 , terminal 2
1h 45m
Seasonal
Embraer 175
UA 4671
United Airlines
11:22 Des Moines International
13:00 , terminal 2
1h 38m
Seasonal
WN 1635
Southwest Airlines
05:55 Des Moines International
07:15 Chicago Midway International
1h 20m
Seasonal
Boeing 737-800
AA 4448
American Airlines
07:36 Des Moines International
09:30 , terminal 3
1h 54m
Seasonal
Embraer EMB 175
AA 3687
American Airlines
10:26 Des Moines International
12:00 , terminal 3
1h 34m
Seasonal
Embraer 170
WN 1635
Southwest Airlines
05:20 Des Moines International
06:45 Chicago Midway International
1h 25m
Seasonal
Boeing 737-800
AA 5226
American Airlines
10:21 Des Moines International
11:59 , terminal 3
1h 38m
Seasonal
Canadair reg jet 700
AA 4448
American Airlines
05:37 Des Moines International
07:21 , terminal 3
1h 44m
Seasonal
Embraer EMB 175
WN 1635
Southwest Airlines
05:10 Des Moines International
06:30 Chicago Midway International
1h 20m
Seasonal
Boeing 737-800
AA 6325
American Airlines
07:14 Des Moines International
09:01 , terminal 3
1h 47m
Seasonal
Canadair reg jet 700
AA 6220
American Airlines
09:45 Des Moines International
11:30 , terminal 3
1h 45m
Seasonal
Canadair reg jet 700
UA 6041
United Airlines
09:37 Des Moines International
11:14 , terminal 2
1h 37m
Seasonal
Embraer 175
UA 6024
United Airlines
05:00 Des Moines International
06:43 , terminal 2
1h 43m
Seasonal
Embraer 175
UA 1856
United Airlines
06:15 Des Moines International
07:51 , terminal 1
1h 36m
Seasonal
Airbus A320
WN 1752
Southwest Airlines
05:40 Des Moines International
07:00 Chicago Midway International
1h 20m
Seasonal
WN 1752
Southwest Airlines
05:20 Des Moines International
06:40 Chicago Midway International
1h 20m
Seasonal
WN 1752
Southwest Airlines
05:15 Des Moines International
06:30 Chicago Midway International
1h 15m
Seasonal
AA 997
American Airlines
06:00 Des Moines International
07:41 , terminal 3
1h 41m
Seasonal
Airbus A319
AA 4417
American Airlines
08:56 Des Moines International
10:36 , terminal 3
1h 40m
Seasonal
Embraer EMB 175
AA 4519
American Airlines
05:00 Des Moines International
06:43 , terminal 3
1h 43m
Seasonal
Embraer EMB 175
AA 4969
American Airlines
08:43 Des Moines International
10:32 , terminal 3
1h 49m
Seasonal
Canadair reg jet 700
AA 4969
American Airlines
09:23 Des Moines International
11:05 , terminal 3
1h 42m
Seasonal
Canadair reg jet 700
AA 4969
American Airlines
09:02 Des Moines International
10:44 , terminal 3
1h 42m
Seasonal
Canadair reg jet 700
AA 4519
American Airlines
06:55 Des Moines International
08:45 , terminal 3
1h 50m
Seasonal
Embraer EMB 175
AA 3852
American Airlines
10:26 Des Moines International
12:05 , terminal 3
1h 39m
Seasonal
Embraer 170

Days of the week are taken from the schedule for the next 14 days; schedules change by season. The search shows seat availability and the price for your date.

Airlines flying Des Moines to Chicago

Flights a week by schedule and the cheapest nonstop fare of each airline found by recent searches

United Airlines28 a week American Airlines19 a week Southwest Airlines8 a week

Airports

Where flights from Des Moines to Chicago depart and land

Departure from Des Moines

Des Moines International DSM

55 flights a week, 4 mi (6 km) from the city centre

About the airport

Arrival in Chicago

Chicago Midway International MDW

8 flights a week, 9 mi (14 km) from the city centre

About the airport

When to visit Chicago

Weather by month

Best time to visit: May, June, July, August, September and October, +18° to +27° by day. In November it is +10° by day and +2° at night, with 7 rainy days.

Jan
0° −7° 10 days
Feb
+2° −6° 7 days
Mar
+9° 0° 12 days
Apr
+14° +5° 13 days
May
+19° +10° 11 days
Jun
+27° +17° 9 days
Jul
+27° +19° 12 days
Aug
+27° +19° 10 days
Sep
+24° +16° 7 days
Oct
+18° +10° 11 days
Nov
+10° +2° 7 days
Dec
+4° −3° 10 days

Daytime and night temperatures in °C, rainy days. Months with the most comfortable weather are in green. Long-term averages.

Frequently asked questions

How long is the flight from Des Moines to Chicago?
A nonstop flight takes 1 hour 40 minutes on average, from 1h 15m to 1h 56m depending on the flight.
How far is Chicago from Des Moines?
309 mi (498 km) in a straight line between the cities.
Which airlines fly nonstop from Des Moines to Chicago?
United Airlines (28 a week), American Airlines (19 a week) and Southwest Airlines (8 a week).
How many flights a day are there from Des Moines to Chicago?
7 flights today and 55 a week, about 7.9 a day on average.
When are the first and last flights from Des Moines to Chicago?
The first departure is at 05:20 (WN1853), the last at 11:23 (UA5304). Local time.
What is the cheapest upcoming date to fly from Des Moines to Chicago?
12 November 2026 (Thursday): from $108 one way, nonstop, by recent searches. The search shows the price for your dates.
Which airline is the cheapest from Des Moines to Chicago?
American Airlines: nonstop tickets from $108 on 12 November by recent searches. Prices change daily, so compare the sellers in the search.
Which Des Moines airport do flights to Chicago leave from?
Des Moines International (55 a week).